Niacinamide (CAS 98-92-0) - Cosmetic Ingredient Introduction
Niacinamide, also known as nicotinamide, is a water-soluble form of vitamin B3 and a versatile staple in modern cosmetics with CAS number 98-92-0. Celebrated for its multi-functional benefits and compatibility with most skin types, it has become a key ingredient in cleansers, serums, moisturizers, and sunscreens. Its popularity stems from its ability to address multiple skin concerns while supporting overall skin health, making it suitable for sensitive, oily, dry, and aging skin.
Core Cosmetic Benefits
- Skin Barrier Strengthening: Boosts ceramide and fatty acid production to reduce transepidermal water loss, enhancing skin resilience against environmental stressors.
- Brightening & Tone Correction: Inhibits melanin transfer to keratinocytes by up to 78% (in vitro study) and fades hyperpigmentation, dark spots, and uneven tone.
- Hydration & Soothing: Calms irritation, reduces redness, and locks in moisture for smoother, more supple skin.
- Anti-Aging & Pore Refinement: Minimizes fine lines, wrinkles, and enlarged pores by regulating sebum production and supporting skin elasticity.
Professional Technical Data
| Parameter |
Specification |
| CAS Number |
98-92-0 |
| IUPAC Name |
Pyridine-3-carboxamide |
| Molecular Formula |
C₆H₆N₂O |
| Molecular Weight |
122.12-122.13 g/mol |
| Physical Form |
White powder or crystals |
| Purity |
≥98.5% (HPLC, dried basis) |
| Melting Point |
128-132 °C |
| Boiling Point |
334-336 °C |
| Water Solubility |
1000-1200 g/L (20 °C) |
| pH Value |
6.0-7.5 (50 g/L in water, 20 °C) |
| Storage Condition |
Cool, dark place (<15 °C), light-sensitive |
| Safety Signal Word |
Warning (eye irritation risk) |
Formulation & Application Notes
Niacinamide is stable in most cosmetic formulations and compatible with ingredients like hyaluronic acid, retinol, and vitamin C when properly dosed (typically 2-10% in products). It is odorless, non-greasy, and readily absorbed by the skin, making it ideal for water-based serums and lightweight creams. For optimal results, it should be stored away from strong oxidizing agents and direct light to maintain potency.
