Products

Ergothioneine

Product ID : 497-30-3

Product Attributes :

Ergothioneine represents a new frontier in antioxidant skincare technology. Its unique ability to target mitochondria, combined with its extraordinary stability and potency, makes it an ideal active ingredient for premium anti-aging, whitening, and protective formulations.

Product Description

Ergothioneine (CAS 497-30-3): The Ultimate Antioxidant for Cosmetics

Product Overview

Ergothioneine (EGT) is a naturally occurring sulfur-containing amino acid derivative with exceptional antioxidant properties. Discovered in 1909 from the fungus Claviceps purpurea, it's now recognized as a powerful "cellular protector" with unique mitochondrial targeting capabilities . Unlike other antioxidants, EGT is taken up by cells through a specific transporter (OCTN1), allowing it to directly protect the energy-producing centers of cells .

Technical Data Sheet

Parameter	Value
CAS Number	497-30-3
Chemical Name	L-(+)-Ergothioneine; 2-thio-L-histidine betaine
Molecular Formula	C₉H₁₅N₃O₂S
Molecular Weight	229.30 g/mol
Appearance	White to off-white crystalline powder
Solubility	Water: ≥46 mg/mL (200.61 mM) at 25°C DMSO/Ethanol: Insoluble
pKa	~7.6 (thiol group)
Stability	Excellent stability at physiological pH; does not auto-oxidize
Purity (Cosmetic Grade)	≥99% (HPLC)
INCI Name	Ergothioneine
Melting Point	195-198°C (decomposes)
Optical Rotation	[α]₂₀^D = +91° (c=1, H₂O)

Mechanism of Action

EGT's efficacy stems from its unique molecular structure and transport mechanism:

Mitochondrial Targeting: Specifically recognized by the OCTN1 transporter, enabling direct delivery to mitochondria (cellular energy factories)
Superior Antioxidant Activity:
- Scavenges hydroxyl radicals with 14× the efficiency of glutathione
- Neutralizes reactive oxygen species (ROS) at 47× the rate of vitamin C
- Protects DNA from oxidative damage
Redox Regulation: Maintains cellular redox balance and enhances endogenous antioxidant defenses
UV Protection: Absorbs UV radiation at wavelengths similar to DNA, acting as a natural sunscreen

Cosmetic Applications & Benefits

Application	Benefits
Anti-Aging Products	Reduces fine lines/wrinkles; improves skin elasticity; prevents glycation
Whitening/Spot-Correcting	Inhibits melanin synthesis; lightens hyperpigmentation (0.01-0.03% concentration effective)
Sun Care	Protects against UV damage; reduces inflammation; accelerates post-sun recovery
Sensitive Skin Formulations	Soothes irritation; strengthens skin barrier; anti-inflammatory
Moisturizers	Enhances hydration retention; improves skin texture

Key Advantages in Cosmetic Formulation

Ultra-Low Effective Dose: Only 0.01-0.1% concentration needed for significant effects
Stability: Remains active in formulations for extended periods
Broad Compatibility: Works synergistically with vitamins C/E, hyaluronic acid, peptides

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