L-Carnosine (CAS 305-84-0) - Cosmetic Raw Material Introduction
L-Carnosine (CAS 305-84-0), a naturally occurring dipeptide composed of β-alanine and L-histidine, is a versatile and high-performance active ingredient in modern cosmetics. Widely present in human muscle, brain, and skin tissues, its concentration declines with age, making it a key target for anti-aging skincare formulations. Renowned for its potent antioxidant, anti-glycation, and anti-inflammatory properties, carnosine effectively addresses multiple skin aging concerns, including wrinkles, sagging, and dullness, making it a staple in premium skincare products.
As a powerful antioxidant, carnosine scavenges harmful free radicals (e.g., hydroxyl radicals, superoxide) and reactive carbonyl species generated by UV radiation, pollution, and oxidative stress. It protects skin cell membranes and mitochondria from lipid peroxidation, extending fibroblast lifespan and maintaining skin vitality. Its unique anti-glycation activity is particularly notable—it mimics collagen's glycation sites to bind reducing sugars first, preventing the formation of advanced glycation end products (AGEs) that cause collagen cross-linking, skin stiffness, and yellowing.
Additionally, carnosine exhibits anti-inflammatory effects by inhibiting pro-inflammatory mediators, soothing sensitive skin and reducing redness. It also supports skin repair by enhancing fibroblast proliferation and migration, accelerating wound healing and improving skin barrier function. With excellent stability, it remains effective over a wide pH range (4-9) and can be added post-emulsification at a recommended dosage of 0.1-0.5%, compatible with other actives like CoQ10, vitamin C, and niacinamide.
Technical Data Sheet
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Item
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Specification
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CAS Number
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305-84-0
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English Name
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L-Carnosine
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Synonyms
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β-Alanyl-L-histidine; N-beta-Alanyl-L-histidine
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Molecular Formula
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C₉H₁₄N₄O₃
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Molecular Weight
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226.23 g/mol
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Appearance
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White to off-white crystalline powder
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Purity (HPLC)
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≥98.0% (typical ≥99%)
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Melting Point
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253°C (decomposes, lit.)
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Boiling Point
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367.84°C (rough estimate)
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Density
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1.2673 (rough estimate)
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pKa
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2.62 (at 25°C)
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Storage Condition
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-20°C (long-term); 2-8°C (short-term)
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EINECS Number
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206-169-9
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With its multifunctional benefits and excellent compatibility, L-Carnosine (CAS 305-84-0) is widely used in anti-aging creams, serums, eye care products, and sensitive skin formulations. It meets global cosmetic ingredient standards, offering a science-backed solution for youthful, healthy skin.
