Tranexamic Acid (CAS 1197-18-8) - Cosmetic Raw Material Introduction
Tranexamic Acid (CAS 1197-18-8), also known as trans-4-(aminomethyl)cyclohexanecarboxylic acid, is a synthetic derivative of the amino acid lysine that has become a staple in whitening and brightening cosmetic formulations. Originally developed as an antifibrinolytic agent for medical hemostasis, its unique mechanism of action in regulating melanin production has made it a highly sought-after cosmetic ingredient, especially favored for its gentle yet effective performance suitable for sensitive skin types.
In cosmetics, tranexamic acid exerts its brightening effect by inhibiting plasminogen activation and tyrosinase activity, two key steps in melanin synthesis. It targets hyperpigmentation at the source, effectively fading dark spots, melasma, post-acne marks, and sun-induced discoloration without irritating the skin barrier. Unlike exfoliating acids, it does not disrupt the skin’s surface layer, making it ideal for long-term use. Additionally, it exhibits anti-inflammatory properties, helping to calm redness and improve overall skin tone uniformity.
This ingredient boasts excellent formulation versatility. As a water-soluble white crystalline powder, it easily integrates into aqueous-based products such as serums, lotions, essences, and masks. It maintains stability under moderate processing temperatures and is compatible with other popular cosmetic actives like niacinamide, vitamin C, and hyaluronic acid, creating synergistic brightening effects. The recommended usage concentration in cosmetics ranges from 0.5% to 3%, compliant with global cosmetic safety standards including China’s Cosmetic Safety Technical Specifications and EU SCCS evaluations.
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Item
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Specification
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Test Method
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CAS Number
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1197-18-8
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——
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Molecular Formula
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C₈H₁₅NO₂
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——
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Molecular Weight
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157.21
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——
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Appearance
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White crystalline powder
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Visual Inspection
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Purity (Assay)
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≥99.0%
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HPLC
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Water Solubility (20℃)
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≥10g/100mL
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Pharmacopoeia General Rule
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Loss on Drying
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≤0.5%
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Karl Fischer Method
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Heavy Metals (as Pb)
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≤10ppm
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ICP-MS
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Melting Point
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＞300℃
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Pharmacopoeia General Rule
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pH Value (1% Aqueous Solution)
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7.0~8.0
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pH Meter
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With its proven efficacy, excellent compatibility, and high safety profile, tranexamic acid has become a core ingredient in premium whitening cosmetics. It offers a gentle solution for consumers seeking to improve uneven skin tone, making it a valuable addition to modern cosmetic formulations.
